Anti- human TIMP1 Antibody, Monoclonal Mouse
Iinkcukacha zemveliso
Iinkcukacha zajikelele
I-TIMP metallopeptidase inhibitor 1, eyaziwa ngokuba yi-TIMP-1/TIMP1, i-Collagenase inhibitor 16C8 fibroblast Umsebenzi we-Erythroid-potentiating, i-TPA-S1TPA-induced proteinTissue inhibitor ye-metalloproteinases 1, yindalo inhibitor ye-metalloptises ye-metalloproteinases inxaxheba ekuthotyweni kwe-matrix ye-extracellular.I-TIMP-1/TIMP1 ifumaneka kwi-fetus kunye nezicubu zabantu abadala.Amanqanaba aphezulu afumaneka kwithambo, imiphunga, i-ovary kunye nesibeleko.I-Complexes ene-metalloproteinases kwaye ingasebenzi ngokungenakuguquleka ngokuzibophelela kwi-catalytic zinc cofactor yazo.I-TIMP-1/TIMP1 ilamla i-erythropoiesis in vitro;kodwa, ngokungafaniyo ne-IL-3, i-specific-specific, ivuselela ukukhula kunye nokuhlukana kwabantu kuphela kunye ne-murine erythroid progenitors.Ukongeza kwindima yayo yokuthintela ngokuchasene neeMMP ezininzi ezaziwayo, iprotheni iyakwazi ukukhuthaza ukwanda kweeseli kwiindidi ezininzi zeeseli, kwaye ingaba nomsebenzi wokuchasana ne-apoptotic.Ushicilelo lwale jini ye-encoding yeprotheyini ithandeka kakhulu ekuphenduleni kwii-cytokines ezininzi kunye neehomoni.Ukongeza, intetho evela kwezinye kodwa ingezizo zonke iichromosomes ze-X ezingasebenziyo zibonisa ukuba olu hlobo lwemfuza lungasebenzi luyipolymorphic kubantu ababhinqileyo.Le gene yokufaka ikhowudi ibekwe ngaphakathi kwe-intron 6 ye-synapsin I gene kwaye ikhutshelwe kwelinye icala.I-Complexes ene-metalloproteinases kwaye ingasebenzi ngokungenakuguquleka ngokuzibophelela kwi-catalytic zinc cofactor yazo.I-TIMP-1/TIMP1 yaziwa ngokusebenza kwi-MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 kunye MMP-16.
Iipropati
| Izindululo ezimbini | I-CLIA (Thatha-Ukufunyanwa): 1D5-5 ~ 3G11-6 1D12-2 ~ 1G3-7 |
| Ubunyulu | >95% njengoko kumiselwe yiSDS-PAGE. |
| Ukuqulunqwa kwesithinteli | PBS, pH7.4. |
| Ugcino | Yigcine phantsi kweemeko ezingakhuselekanga ku -20℃ ukuya -80℃ xa uyifumene. Ncoma ukuba i-aliquot iprotheni ibe yimiyinge emincinci yokugcina eyona ilungileyo. |
Uthelekiso lokukhuphisana
Ulwazi lweodolo
| Igama lemveliso | Ikati.Hayi | Clone ID |
| I-TIMP1 | AB0034-1 | 1D5-5 |
| AB0034-2 | 1D12-2 | |
| AB0034-3 | 1G3-7 | |
| AB0034-4 | 3G11-6 |
Qaphela: I-Bioantibody inokuhlengahlengiswa ngokwemfuno yakho.
Ucaphulo
1.Barylski M , Kowalczyk E , Szadkowska I , et al.[I-tissue inhibitor ye-metalloproteinases[J].Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego, 2011, 30(178): 246-8.
2.Hayakawa T , Yamashita K , Tanzawa K , et al.Ukukhula komsebenzi we-tissue inhibitor ye-metalloproteinases-1 (TIMP-1) kuluhlu olubanzi lweeseli Into entsha enokwenzeka yokukhula kwiserum[J].Iileta zeFEBS, 1992, 298.
3.Haider DG , Karin S , Gerhard P , et al.I-Serum retinol-binding protein 4 iyancitshiswa emva kokwehla kobunzima kwizifundo ezityebe ngokugqithisileyo.[J].Ijenali yeClinical Endocrinology & Metabolism (3): 1168-71.
