Anti- human CHI3L1 Antibody, umntu Monoclonal
Iinkcukacha zemveliso
Iinkcukacha zajikelele
Iprotheyini ye-Chitinase-3 efana ne-1 (i-CHI3L1) i-glycoprotein efihliweyo ye-heparin-intetho yayo ihambelana ne-vascular smooth muscle cell migration.I-CHI3L1 ibonakaliswe kumanqanaba aphezulu kwiinkcubeko ze-VSMC ze-postconfluent nodular kunye namanqanaba aphantsi kwiinkcubeko ezikhulayo.I-CHI3L1 yi-tissue-restricted, i-chitin-binding lectin kunye nelungu le-glycosyl hydrolase yosapho 18. Ngokuchaseneyo nezinye iimpawu ezininzi ze-monocyto / macrophage, inkcazo yayo ayikho kwi-monocytes kwaye i-induced eyomeleleyo ngexesha lokuhlukana kwe-macrophage yabantu.Amanqanaba aphakamileyo e-CHI3L1 anxulunyaniswa nokuphazamiseka okubonisa ukwanda kwezicubu ezixhumeneyo, ezifana ne-rheum atoid, i-arthritis, i-osteoarthritis, i-scleroderma, kunye ne-cirrhosis yesibindi, kodwa iveliswa kwi-cartilage evela kubaxhasi abadala okanye izigulane ezine-osteoarthritis.I-CHI3L1 ibonakaliswe ngokungaqhelekanga kwi-hippocampus yezifundo ezine-schizophrenia kwaye inokubandakanyeka kwimpendulo yeselula kwiziganeko ezahlukeneyo zokusingqongileyo ezichazwe ukuba zandise umngcipheko we-schizophrenia.
Iipropati
| Izindululo ezimbini | I-CLIA (Thatha-Ukufunyanwa): 2E4-2 ~ 1G11-14 13F3-1 ~ 1G11-14 |
| Ubunyulu | >95%, igqitywe yiSDS-PAGE |
| Ukuqulunqwa kwesithinteli | PBS, pH7.4 |
| Ugcino | Yigcine phantsi kweemeko ezingakhuselekanga ku -20℃ ukuya -80℃ xa uyifumene. Ukugcina ixesha elide, nceda aliquot kwaye uyigcine.Kuphephe ukukhenkceza okuphindaphindiweyo kunye nemijikelo yokunyibilika. |
Uhlalutyo lokuthelekisa
| I-bioantibody | ityala elifunyaniswe ngonyango | Iyonke | |
| entle | Ibi | ||
| entle | 46 | 3 | 49 |
| Ibi | 4 | 97 | 101 |
| Iyonke | 50 | 100 | 150 |
| isalathisi sovavanyo | ubuntununtunu | iinkcukacha ezithile | ukuchaneka |
| 92% | 97% | 95% | |
Ulwazi lweodolo
| Igama lemveliso | Ikati.Hayi | Clone ID |
| I-CHI3L1 | AB0031-1 | 1G11-14 |
| AB0031-2 | 2E4-2 | |
| AB0031-3 | 3A12-1 | |
| AB0031-4 | 13F3-1 |
Qaphela: I-Bioantibody inokuhlengahlengiswa ngokwemfuno yakho.
Ucaphulo
1.Kyrgios I , Galli-Tsinopoulou A , Stylianou C , et al.Amanqanaba aphakamileyo ajikelezayo e-serum acute-phase protein YKL-40 (chitinase 3-like protein 1) luphawu lokutyeba nokunganyangeki kwe-insulin kubantwana abangaphambi kokufikisa[J].I-Metabolism-clinical & Experimental, 2012, 61 (4): 562-568.
2.Yu-Huan M , Li-Ming T , Jian-Ying LI , et al.Uvavanyo ekusetyenzisweni kwe-serum chitinase-3-like protein 1, alpha-fetoprotein kunye nokufumanisa i-ferritin ukuxilonga i-hepatocellular carcinoma[J].Unyango oluSebenzayo loThintelo, ngo-2018.
