Anti-human PLGF Antibody, Monoclonal Mouse
Iinkcukacha zemveliso
Iinkcukacha zajikelele
I-Preeclampsia (PE) yingxaki enkulu yokukhulelwa ebonakaliswe yi-hypertension kunye ne-proteinuria emva kweeveki ezingama-20 zokukhulelwa.I-Preeclampsia yenzeka kwi-3-5% yokukhulelwa kwaye ikhokelela ekuswelekeni okukhulu komama kunye nosana olungekazalwa okanye olusanda kuzalwa kunye nokugula.Ukubonakaliswa kweklinikhi kunokuhluka ukusuka kwiifom ezincinci ukuya kwiifom ezinzima;I-preeclampsia isengomnye woonobangela abaphambili bokugula nokufa komntwana ongekazalwa kunye nomama.
I-Preeclampsia ibonakala ibangelwa ukukhutshwa kwezinto ze-angiogenic kwi-placenta eyenza ukungasebenzi kakuhle kwe-endothelial.Amanqanaba eSerum ye-PLGF (i-placental growth factor) kunye ne-sFlt-1 (enyibilikayo fms-efana ne-tyrosine kinase-1, ekwaziwa njenge-soluble VEGF receptor-1) iyatshintshwa kubasetyhini abane-preeclampsia.Ngaphezu koko, amanqanaba ajikelezayo e-PLGF kunye ne-sFlt-1 inokucalula ukukhulelwa okuqhelekileyo kwi-preeclampsia nangaphambi kokuba iimpawu zekliniki zenzeke.Kukukhulelwa okuqhelekileyo, i-pro-angiogenic factor PlGF iyanda kwi-trimester yokuqala kwaye yehla njengoko ukukhulelwa kuhambela phambili.Ngokwahlukileyo, amanqanaba e-anti-angiogenic factor sFlt-1 ahlala ezinzile ngexesha lokuqala kunye nenqanaba eliphakathi lokumitha kwaye anda ngokuthe chu kude kube lixesha.Kwabasetyhini abaphuhla i-preeclampsia, amanqanaba e-sFlt-1 afunyenwe engaphezulu kwaye amanqanaba e-PlGF afunyenwe esezantsi kunokukhulelwa okuqhelekileyo.
Iipropati
| Izindululo ezimbini | I-CLIA (Thatha-Ukufunyanwa): 7G1-2 ~ 5D9-3 5D9-3 ~ 7G1-2 |
| Ubunyulu | >95% njengoko kumiselwe yiSDS-PAGE. |
| Ukuqulunqwa kwesithinteli | PBS, pH7.4. |
| Ugcino | Yigcine phantsi kweemeko ezingakhuselekanga ku -20℃ ukuya -80℃ xa uyifumene. Ncoma ukuba i-aliquot iprotheni ibe yimiyinge emincinci yokugcina eyona ilungileyo. |
Uthelekiso lokukhuphisana
Ulwazi lweodolo
| Igama lemveliso | Ikati.Hayi | Clone ID |
| PLGF | AB0036-1 | 7G1-2 |
| AB0036-2 | 5D9-3 | |
| AB0036-3 | 5G7-1 |
Qaphela: I-Bioantibody inokuhlengahlengiswa ngokwemfuno yakho.
Ucaphulo
1.Brown MA, Lindheimer MD, de Swiet M, et al.Ukwahlula kunye nokuxilongwa kweengxaki ze-hypertension yokukhulelwa: ingxelo evela kwi-International Society for the Study of Hypertension in Pregnancy (ISSHP).I-Hypertens Pregnancy 2001;20(1):IX-XIV.
2.Uzan J, Carbonnel M, Piconne O, et al.I-Pre-eclampsia: i-pathophysiology, ukuxilongwa, kunye nokulawula.I-Vasc Health Risk Manag 2011; 7: 467-474.
