Anti- human IGFBP-1 Antibody, Monoclonal Mouse
Iinkcukacha zemveliso
Iinkcukacha zajikelele
I-IGFBP1, eyaziwa ngokuba yi-IGFBP-1 kunye ne-insulin-efana ne-insulin-efana ne-protein ebopha i-protein ye-1, lilungu le-insulin-like ukukhula factor-binding usapho lweprotheyini.Iiprotheyini zokubopha i-IGF (IGFBPs) ziiprotheyini ze-24 ukuya kwi-45 kDa.Zonke ii-IGFBP ezintandathu zabelana nge-50% ye-homology kwaye zine-affinities ezibophezelayo ze-IGF-I kunye ne-IGF-II ngomyalelo ofanayo wobukhulu njengoko i-ligands ine-IGF-IR.Iiprotheyini ezibophelelayo ze-IGF zandisa ubude besiqingatha sobomi be-IGF kwaye zibonakaliswe ukuba zinqanda okanye zivuselele imiphumo yokukhuthaza ukukhula kwe-IGF kwinkcubeko yeseli.Batshintsha intsebenziswano ye-IGF kunye ne-cell surface receptors.I-IGFBP1 ine-domain ye-IGFBP kunye ne-thyroglobulin type-I domain.Ibophelela zombini izinto zokukhula ezifana ne-insulin (IGFs) I kunye ne-II kwaye ijikeleza kwi-plasma.Ukubotshwa kwale proteni kwandisa isiqingatha sobomi be-IGF kunye nokuguqula ukusebenzisana kwabo kunye ne-cell surface receptors.
Iipropati
| Izindululo ezimbini | I-CLIA (Thatha-Ukufunyanwa): 4H6-2 ~ 4C2-3 4H6-2 ~ 2H11-1 |
| Ubunyulu | >95% njengoko kumiselwe yiSDS-PAGE. |
| Ukuqulunqwa kwesithinteli | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300,pH7.4 |
| Ugcino | Yigcine phantsi kweemeko ezingakhuselekanga ku -20℃ ukuya -80℃ xa uyifumene. Ncoma ukuba i-aliquot iprotheni ibe yimiyinge emincinci yokugcina eyona ilungileyo. |
Uthelekiso lokukhuphisana
| I-bioantibody | Ityala elifunyenwe nguNyango | Iyonke | |
| Okuhle | Ibi | ||
| Okuhle | 35 | 0 | 35 |
| Ibi | 1 | 87 | 88 |
| Iyonke | 36 | 87 | 123 |
| Ukuchaza ngokuthe ngqo | 100% | ||
| Uvakalelo | 97% | ||
Ulwazi lweodolo
| Igama lemveliso | Ikati.Hayi | Clone ID |
| IGFBP-1 | AB0028-1 | 4H6-2 |
| AB0028-2 | 4C2-3 | |
| AB0028-3 | 2H11-1 | |
| AB0028-4 | 3G12-11 |
Qaphela: I-Bioantibody inokuhlengahlengiswa ngokwemfuno yakho.
Ucaphulo
1.Rutanen EM .Into yokukhula efana ne-insulin ebophelela iprotheyini 1: US 1996.
2.Harman, S, Mitchell, et al.Amanqanaba eSerum e-Insulin-Like Growth Factor I (IGF-I), i-IGF-II, i-IGF-Binding Protein-3, kunye ne-Prostate-Specific Antigen njengeZibikezelo zeClinical Prostate Cancer [J].Ijenali yeClinical Endocrinology & Metabolism, 2000.
