Antibody MMP-3 Antibody, Monoclonal Mouse
Iinkcukacha zemveliso
Iinkcukacha zajikelele
I-Matrix metallopeptidase 3 (efinyeziweyo njenge-MMP3) ikwabizwa ngokuba yi-stromelysin 1 kunye ne-progelatinase.I-MMP3 lilungu lentsapho ye-matrix metalloproteinase (MMP) amalungu alo abandakanyekayo ekuqhekekeni kwe-matrix engaphandle kwe-extracellular matrix kwiinkqubo eziqhelekileyo ze-physiological, ezifana nophuhliso lwe-embryonic, ukuveliswa, ukuhlaziywa kwezicubu, kunye neenkqubo zezifo ezibandakanya i-arthritis kunye ne-metastasis.Njenge-endopeptidase exhomekeke kwi-zinc, i-MMP3 yenza imisebenzi yayo ikakhulu kwi-matrix engaphandle kweseli.Le proteni isebenze ziinhibitors ezimbini eziphambili ze-endogenous: i-alpha2-macroglobulin kunye ne-tissue inhibitors ye-metalloproteases (TIMPs).I-MMP3 idlala indima ephambili ekuthotyweni kweentlobo ze-collagen II, III, IV, IX, kunye ne-X, i-proteoglycans, i-fibronectin, i-laminin, kunye ne-elastin.Kwakhona, i-MMP3 inokusebenza ezinye ii-MMP ezifana ne-MMP1, i-MMP7, kunye ne-MMP9, yenza i-MMP3 ibaluleke kakhulu kuhlengahlengiso oludibanisayo.I-Dysregulation ye-MMPs iye yabandakanyeka kwizifo ezininzi ezibandakanya i-arthritis, izilonda ezingapheliyo, i-encephalomyelitis, kunye nomhlaza.I-Synthetic okanye i-natural inhibitors ye-MMPs ibangela ukuvinjelwa kwe-metastasis, ngelixa ukunyuswa kwe-MMPs kukhokelela ekuhlaselweni kweeseli zomhlaza.
Iipropati
| Izindululo ezimbini | I-CLIA (Thatha-Ukufunyanwa): 11G11-6 ~ 8A3-9 11G11-6 ~ 5B9-4 |
| Ubunyulu | >95%, igqitywe yiSDS-PAGE |
| Ukuqulunqwa kwesithinteli | PBS, pH7.4. |
| Ugcino | Yigcine phantsi kweemeko ezingakhuselekanga ku -20℃ ukuya -80℃ xa uyifumene. Ncoma ukuba i-aliquot iprotheni ibe yimiyinge emincinci yokugcina eyona ilungileyo. |
Uthelekiso lokukhuphisana
Ulwazi lweodolo
| Igama lemveliso | Ikati.Hayi | Clone ID |
| MMP-3 | AB0025-1 | 11G11-6 |
| AB0025-2 | 8A3-9 | |
| AB0025-3 | 5B9-4 |
Qaphela: I-Bioantibody inokuhlengahlengiswa ngokwemfuno yakho.
Ucaphulo
1.Yamanaka H , Matsuda Y , Tanaka M , et al.ISerum matrix metalloproteinase 3 njengengqikelelo yeqondo lokutshabalalisa ngokudibeneyo ngexesha leenyanga ezintandathu emva komlinganiselo, kwizigulane ezine-rheumatoid arthritis yokuqala[J].I-Arthritis & Rheumatism, 2000, 43 (4): 852-858.
2.Hattori Y , Kida D , Kaneko A .Amanqanaba aqhelekileyo e-serum matrix metalloproteinase-3 angasetyenziselwa ukuqikelela ukuxolelwa kwekliniki kunye nomsebenzi oqhelekileyo womzimba kwizigulane ezine-rheumatoid arthritis [J].I-Clinical Rheumatology, ngo-2018.
