I-PIVKA echasene nomntu -II i-Antibody, iMouse Monoclonal
Iinkcukacha zemveliso
Iinkcukacha zajikelele
Iprotheyini ebangelwa yi-Vitamin K Ukungabikho okanye i-Antagonist-II (PIVKA-II), eyaziwa ngokuba yi-Des-γ-carboxy-prothrombin (DCP), yindlela engaqhelekanga yeprothrombin.Ngokuqhelekileyo, i-prothrombin's 10 glutamic acid residues (Glu) kwi-γ-carboxyglutamic acid (Gla) isizinda kwindawo ye-6, 7, 14, 16, 19, 20,25, 26, 29 kunye ne-32 yi-γ-carboxylated kwi-Glavithamini. -K exhomekeke kwi-γ- glutamyl carboxylase kwisibindi kwaye emva koko ikhutshwe kwi-plasma.Kwizigulane ezine-hepatocellular carcinoma (HCC), i-γ-carboxylation ye-prothrombin iphazamisekile ukwenzela ukuba i-PIVKA-II yenziwe endaweni yeprothrombin.I-PIVKA-II ithathwa njenge-biomarker efanelekileyo ye-HCC.
Iipropati
| Izindululo ezimbini | I-CLIA (Thatha-Ukufunyanwa): 1E5-1 ~ 1D6-10 1E5-1 ~ 1E6-7 |
| Ubunyulu | >95%, igqitywe yiSDS-PAGE |
| Ukuqulunqwa kwesithinteli | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300, pH7.4 |
| Ugcino | Yigcine phantsi kweemeko ezingakhuselekanga ku -20℃ ukuya -80℃ xa uyifumene. Ukugcina ixesha elide, nceda aliquot kwaye uyigcine.Kuphephe ukukhenkceza okuphindaphindiweyo kunye nemijikelo yokunyibilika. |
Uhlalutyo lokuthelekisa
Ulwazi lweodolo
| Igama lemveliso | Ikati.Hayi | Clone ID |
| I-PIVKA-Ⅱ | AB0009-1 | 1F4-5 |
| AB0009-2 | 1E5-1 | |
| AB0009-3 | 1D6-10 | |
| AB0009-4 | 1E6-7 |
Qaphela: I-Bioantibody inokuhlengahlengiswa ngokwemfuno yakho.
Ucaphulo
1.Matsueda K, Yamamoto H, Yoshida Y, et al.I-Hepatoid carcinoma ye-pancreas evelisa iprotheni ebangelwa ukungabikho kwe-vitamin K okanye i-antagonist II (PIVKA-II) kunye ne-α-fetoprotein (AFP) [J].Ijenali yeGastroenterology, 2006, 41 (10): 1011-1019.
2.Viggiani, Valentina, Palombi,等.Iprotheyini ebangelwa yi-vitamin K ukungabikho okanye i-antagonist-II (PIVKA-II) yanda ngokukodwa kwizigulane ze-hepatocellular carcinoma zase-Italian.[J].Ijenali yaseScandinavia yeGastroenterology, ngo-2016.
3.Simundic AM .Iingcebiso ezisebenzayo zohlalutyo lweenkcukacha-manani kunye nokunikezelwa kwedatha kwijenali ye-Biochemia Medica[J].I-Biochemia Medica, i-2012, i-22 (1).
4.Tartaglione S , Pecorella I , Zarrillo SR , et al.Iprotheyini Eyenziwe yiVithamin K Ukungabikho II (PIVKA-II) njengento enokubakho ye-serological biomarker kumhlaza wepancreatic: isifundo sokulinga[J].I-Biochemia Medica, 2019, 29(2).
