Iinkcukacha zajikelele
Umkhuhlane, okanye umkhuhlane, sisifo esosulelayo sokuphefumla esibangelwa ziintsholongwane ezahlukeneyo zomkhuhlane.Iimpawu zomkhuhlane ziquka ukuqaqanjelwa kwezihlunu kunye nokuqaqamba, intloko ebuhlungu, nomkhuhlane.Uhlobo A lwentsholongwane yomkhuhlane ihlala itshintsha kwaye inoxanduva ngokubanzi kwizibetho zomkhuhlane omkhulu.
Umkhuhlane A unokohlulwa ube ziindidi ezincinci ezahlukeneyo ngokusekelwe kwindibaniselwano yeeprotheyini ezimbini kumphezulu wentsholongwane egazini: ihemagglutinin (H) kunye neuraminidase (N).
Izindululo ezimbini | IC(Thatha-Ukufumanisa): 1B5-6 ~ 3A9-8 |
Ubunyulu | >95%, igqitywe yiSDS-PAGE |
Ukuqulunqwa kwesithinteli | PBS, pH7.4. |
Ugcino | Yigcine phantsi kweemeko ezingcolileyo kwi -20℃ukuya kwi-80℃ekufumaneni. Ncoma ukuba i-aliquot iprotheni ibe yimiyinge emincinci yokugcina eyona ilungileyo. |
Igama lemveliso | Ikati.Hayi | Clone ID |
Umkhuhlane A | AB0023-1 | 1F10-1 |
AB0023-2 | 1B5-6 | |
AB0023-3 | 3A9-8 |
Qaphela: I-Bioantibody inokuhlengahlengiswa ngokwemfuno yakho.
1.Senne DA , Panigrahy B , Kawaoka Y , et al.Uphononongo lwe-hemagglutinin (HA) yolandelelwano lwesiza sokuqhekeza i-H5 kunye ne-H7 yeentsholongwane zomkhuhlane we-avian: ulandelelwano lwe-amino acid kwindawo ye-HA yokuqhekeka njengophawu lwesakhono se-pathogenicity.[J].Izifo ze-Avian, i-1996, i-40 (2): 425-437.
2.Benton DJ , Gamblin SJ , Rosenthal PB , et al.Utshintsho lwesakhiwo kwi-influenza haemagglutinin kwi-membrane fusion pH[J].Indalo, 2020:1-4.
3.1.Urai C, Wanpen C. Evolution of therapeutic Antibodies, Influenza Virus Biology, Influenza, kunye ne-Influenza Immunotherapy.Biomed Res Int.2018.
4.2.UFlorian K. I-antibody yokusabela kusulelo lwentsholongwane yomkhuhlane kunye nogonyo.Indalo iphonononga i-immunology.2019, 19, 383-397.