I-Helicobacter pylori (HP) yibhaktheriya ehlala kwisisu kwaye ibambelele kwi-gastric mucosa kunye nezithuba ze-intercellular, ezibangela ukuvuvukala.Usulelo lwe-HP lolunye usulelo oluxhaphakileyo lwebhaktiriya, losulela amawaka ezigidi zabantu kwihlabathi liphela.Ziyimbangela ehamba phambili yezilonda kunye ne-gastritis (ukuvuvukala kwentambo yesisu).

Usulelo oluphezulu ebantwaneni kunye nokudityaniswa kosapho ziimpawu ezibalulekileyo zosulelo lwe-HP, kwaye usulelo losapho lunokuba yeyona ndlela iphambili usulelo lwe-HP yeyona nto ingunobangela kwi-gastritis esebenzayo engapheliyo, isilonda se-peptic, i-gastric mucosa-associated lymphoid tissue (MALT) lymphoma, kunye umhlaza wesisu.Kwi-1994, i-World Health Organization / i-Arhente yeZizwe ngezizwe yoPhando lweCancer (WHO / IARC) ikhethe i-Helicobacter pylori njengeklasi I carcinogen

I-gastric mucosa - isikrweqe somzimba wesisu

Kwiimeko eziqhelekileyo, udonga lwesisu lunoluhlu lweendlela ezigqibeleleyo zokuzikhusela (i-secretion ye-gastric acid kunye ne-protease, ukukhuselwa kwe-mucus enganyibilikiyo kunye ne-soluble layers, umthambo oqhelekileyo, njl. abangena ngomlomo.

I-HP ine-flagella ezimeleyo kunye nesakhiwo esiyingqayizivele se-helical, engadlali kuphela indima ye-anchoring ngexesha lekholoni yebhaktheriya, kodwa inokuba yi-spherical kwaye yenze i-morphology yokuzikhusela kwiindawo ezinzima.Ngelo xesha, i-Helicobacter pylori inokuvelisa iintlobo ze-toxins, ezibonisa ukuba i-Helicobacter pylori inokudlula kwi-gastric juice layer ngokusebenzisa amandla ayo kwaye ixhathise i-asidi ye-gastric kunye nezinye izinto ezingathandekiyo, ibe yi-microorganism kuphela enokuthi iphile kwisisu somntu. .

I-Pathogenesis ye-Helicobacter pylori

1. Inamandla

Uphononongo lubonise ukuba i-Helicobacter pylori inamandla okuhamba kwindawo ye-viscous, kwaye i-flagella iyimfuneko ukuba ibhaktheriya ibhukude kwindawo ekhuselayo ye-mucus ebusweni be-gastric mucosa.

2. Iprotheyini ehambelana ne-Endotoxin A (CagA) kunye ne-toxin ye-vacuolar (VacA)

I-Cytotoxin-ehambelana ne-gene A (CagA) iprotheni efihliweyo yi-HP inokubangela impendulo yendawo yokuvuvukala.Usulelo lwe-CagA-positive Helicobacter pylori lunokwandisa kakhulu umngcipheko we-atrophic gastritis, i-intestinal metaplasia kunye nomhlaza wesisu.

I-Vacuolating cytotoxin A (VacA) yenye eyona nto ibalulekileyo ye-pathogenic factor ye-Helicobacter pylori, enokungena kwi-mitochondria ukulawula umsebenzi we-organelles.

3. Flagellin

Iiprotheni ezimbini ze-flagellin, i-FlaA kunye ne-FlaB, zenza amacandelo amakhulu e-flagellar filaments.Utshintsho kwi-flagellin glycosylation luchaphazela i-strain motility.Xa inqanaba le-FlaA protein glycosylation lanyuswa, zombini amandla okufuduka kunye nomthwalo wekoloniyali yoxinzelelo lwenyuka.

4. Urease

I-Urease yenza i-NH3 kunye ne-CO2 nge-hydrolyzing urea, eyenza i-acidity yesisu kwaye iphakamise i-pH yeeseli ezijikelezileyo.Ukongezelela, i-urease ithatha inxaxheba kwiimpendulo ezivuthayo kwaye ikhuthaza ukunamathela ngokusebenzisana ne-CD74 receptors kwiiseli ze-epithelial zesisu.

5. Iprotheyini yokothuka ubushushu HSP60/GroEL

I-Helicobacter pylori ifunxa uthotho lweeproteni ezothusayo zobushushu ezigcinwe kakhulu, apho ukubonakaliswa kwe-Hsp60 kunye ne-urease kwi-E. coli kwandisa kakhulu umsebenzi we-urease, okuvumela i-pathogen ukuba ilungelelanise kwaye iphile kwindawo enobutshaba ye-ecological niche yesisu somntu.

6. Iprotheyini enxulumene ne-Hook 2 homolog FliD

I-FliD yiprotheyini yesakhiwo ekhusela incam ye-flagellar kwaye inokuphinda ifake i-flagellar ukuze ikhulise imicu ye-flagellar.I-FliD iphinda isetyenziswe njenge-adhesion molekyuli, iqonda iimolekyuli ze-glycosaminoglycan zeeseli ezibambayo.Kwiinginginya ezosulelekileyo, izilwa-buhlungu ezichasene ne-flid ziziphawuli zosulelo kwaye zinokusetyenziselwa ukuxilongwa kwe-serological.

Iindlela zoVavanyo:

1. Uvavanyo lwesitulo: Uvavanyo lwe-antigen ye-stool luvavanyo olungena-invasive lwe-H. pylori.Umsebenzi ukhuselekile, ulula kwaye uyakhawuleza, kwaye awufuni ukulawulwa ngomlomo kwanoma yiyiphi i-reagents.

2. Ukufunyanwa kwe-Serum antibody: Xa usulelo lwe-Helicobacter pylori lwenzeka emzimbeni, umzimba womntu uya kuba ne-anti-Helicobacter pylori antibodies egazini ngenxa yokusabela komzimba.Ngokutsala igazi ukujonga ukuxinwa kwee-antibodies ze-Helicobacter pylori, kunokubonisa ukuba kukho i-Helicobacter pylori emzimbeni.usulelo lwebhaktiriya.

3. Uvavanyo lokuphefumla: Le yeyona ndlela idumileyo yokuhlola okwangoku.I-urea yomlomo equkethe i-13C okanye i-14C, kunye nokuhlolwa kokuphefumula kwe-carbon dioxide equkethe i-13C okanye i-14C emva kwexesha elithile, kuba ukuba kukho i-Helicobacter pylori, i-urea iya kubonwa yi-urea yayo ethile.Iienzymes ziyaqhekeka zibe yiammonia kunye nekharbon diokside, ethi ikhutshwe emiphungeni ngegazi.

4. I-Endoscopy: ivumela ukuqwalaselwa ngokucophelela kweempawu ze-mucosal zesisu ezifana nokubomvu, ukuvuvukala, utshintsho lwe-nodular, njl.;I-endoscopy ayifanelekanga kwizigulane ezineengxaki ezinzima okanye ezichasayo kunye neendleko ezongezelelweyo (i-anesthesia, i-forceps) ).

Iimveliso ezinxulumene ne-bioantibody ze-H.ipyloriiingcebiso:

H. Pylori Antigen Rapid Test Kit (Lateral Chromatography)

H. Pylori Antibody Rapid Test Kit (Lateral Chromatography)